(Part 1) DNA gyrase could be a crucial regulatory factor for growth and survival of <i>Mycobacterium leprae</i>

Leprosy, an important infectious disease in humans caused by Mycobacterium leprae (Mle), remains endemic many countries. Of note, the pathogen cannot be cultured vitro. In addition, Mle grows optimally at 30 to 33℃, while other mycobacteria grow 37 42℃. The molecular bases of these characteristics, as well mechanisms remain unknown. Consequently, analysis growth and survival is urgently needed develop novel therapies, such rapid, simple, specific methods detect infection against leprosy. this study, we functionally characterized vitro Mle-DNA gyrase promote bacterial survival. From our result, propose that DNA makes a significant contribution survival, one few clinically validated targets for antimicrobial agents.